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Isoniazid Isoniazid inhibits the CYP2C19 and CYP3A4 metabolic pathway for diazepam. Co-administration with 90 mg isoniazid two times everyday for 3 days resulted in a protracted elimination half-lifetime of diazepam As well as in a 35% enhanced plasma concentration (AUC) of diazepam. Amplified outcome of diazepam.
A proposed mechanism is competitive binding of theophylline to adenosine receptors from the Mind. Counteraction from the pharmacodynamic outcomes of diazepam, e.g. reduction of sedation and psychomotor results.
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